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KMID : 0383820080640060422
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Tuberculosis and Respiratory Diseases
2008 Volume.64 No. 6 p.422 ~ p.426
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Detection of Clarithromycin-resistant Strains from Clinical Isolates of Mycobacterium abscessus
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Lee Seung-Heon
Park Young-Kil
Ryoo Sung-Weon
Shim Myung-Sup
Lew Woo-Jin
Kim Hee-Jin
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Abstract
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Background: Mycobacterium abscessus is the most pathogenic and drug-resistant rapid-growing mycobacterium. Clarithromycin or azithromycin are the only regular oral antimycobacterial agents that have an effect on M. abscessus. We tried to detect the clarithromycin-resistant strains from the clinical isolates of M. abscessus.
Methods: We tried to isolate the clarithromycin-resistant strains from 220 clinical isolates of M. abscessus by performing using reverse hybridization assay (RHA) and the broth microdilution test (BMT).
Results: Seven resistant strains (3.2%) from all the tested clinical isolates were detected by BMT. Three of these resistant strains were also detected by RHA and it was confirmed that they had point mutants.
Conclusion: These results showed that clarithromycin resistance in M. abscessus clinical isolates is related to a point mutation and other unknown mechanisms. (Tuberc Respir Dis 2008;64:422-426)
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KEYWORD
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Mycobacteriumabscessus, Reversehybridizationassay, Brothmicrodilutiontest, 23SrRNA, Clarithromycin
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